Substituted by cognate residues from Gz. Interestingly, an intact N-terminal helical
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Published date: 2024/09/19
- Location: 35701-171, Sabhā, Libya
Substituted by cognate residues from Gz. Interestingly, an intact N-terminal helical domain (A-F) of G14 are seemingly important for G14-mediated PLC activation. G14 chimeras with A-F replaced entirely or in part by Gz can be expressed at a detectable level but failed to interact with PLC2 or stimulate IP3 Lenvatinib production.Discussion Structure and function correlations of members within the same protein family are often based on extensive analyses of a prototypical member. In the case of the Gq family, it is generally assumed that all members interact with the canonical effector PLC in much the same way as Gq. The biochemical functions of Gq family members are almost indistinguishable [33, 37] except for their ability to recognize specific receptors [38].
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